描述Thermo Scientific Imject Alum Adjuvant is a formulation of aluminum hydroxide and magnesium hydroxide that effectively stimulates the immune response for antibody production procedures when mixed and injected with prepared immunogens.Alum is considerably easier to mix with immunogens than Freund's adjuvants, as it does not require laborious emulsification. Although its effects are less pronounced compared to Freund's complete adjuvant (CFA), Imject Alum produces sufficient stimulation when used with complex immunogens (i.e., those that have been prepared as conjugates with KLH or other immunogenic carrier proteins). Features of Pierce Imject Alum Adjuvant: • Suspension of aluminum hydroxide and magnesium hydroxide • Mild but effective adjuvant for substantial immunogens • Ready to use: mix antigen directly with Imject Alum and inject • The adjuvant of choice for allergy and immunogenicity testing with or without sensitization and challenge with fraction V ovalbumin (OVA) (see Moisan and Pongratz references) • Disadvantage: does not elicit as strong an immune response as CFA; requires a strong immunogen Adjuvants are nonspecific stimulators of the immune response. When mixed with an antigen or immunogen, adjuvants help to deposit or sequester the injected material thereby helping to increase antibody response. Adjuvants enhance the immune response to compounds that are already immunogenic; they do not confer immunogenicity to non-immunogenic haptens. To make prospective antigens more immunogenic, it is necessary to conjugate them to a carrier protein or some other complex, immunogenic molecule. |
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