描述The Thermo Scientific Pierce RED Device for Rapid Equilibrium Dialysis provides the easiest, fastest and most reliable system for performing plasma protein-binding assays, a critical step in drug development. This product includes a single-use plate with 8K MWCO inserts.Features of the RED Device for Rapid Equilibrium Dialysis: • Easy and ready to use—disposable tubes require no presoaking, assembly or specialized equipment • Designed for speed—the high surface-to-volume ratio of the insert design enables equilibrium to be reached in as few as 100 minutes with vigorous agitation or in three to four hours with 200rpm agitation • Automation-compatible—designed on a standard 96-well plate template suitable for automated liquid handlers • Flexible and scalable—perform any number of assays (1 to 48 assays per plate) without wasting the entire plate • Robust—compartmentalized design eliminates potential for cross talk or leakage • Reproducible and accurate—validated for plasma binding assays, producing results consistent with those reported in literature • Quality-tested—each lot of inserts is functionally tested in a protein-binding assay for guaranteed performance The Pierce Device for rapid equilibrium dialysis (RED) was developed in association with the pharmaceutical industry to provide the easiest, fastest and most reliable system for performing plasma protein-binding assays. The RED Device is an apparatus for performing equilibrium dialysis experiments in a high throughput, automation-compatible format, and consists of disposable inserts and a base plate formatted to a standard microplate footprint. It has been extensively validated for plasma-binding assays and produces results consistent with those reported in the literature. The RED Device also offers significant improvements in automation, time requirements, versatility and product reliability compared to other commercially available equilibrium dialysis systems. Features of the RED Device Inserts: Each single-use, disposable insert is made of two side-by-side chambers separated by a vertical cylinder of dialysis membrane (in 8K or 12K MWCO) validated for minimal nonspecific binding. This format requires no extensive assembly steps or specialized equipment, and each chamber or well is easily accessible from the top of the insert after insertion in the base plate. Additionally, the high surface-to-volume ratio of the membrane compartment allows rapid dialysis, where equilibrium can be reached in 4 hours with high levels of reproducibility and accuracy. In many cases, experiments can be completed in less than 100 minutes. Insert Features: • Disposable: require no presoaking, assembly, or specialized equipment • Short incubation time: large dialysis surface area accelerates equilibrium • 8K MWCO membrane: ideal molecular-weight cutoff for protein-drug binding studies • 12K MWCO membrane also available for larger drug molecules • Membrane composition: regenerated cellulose with low glycerol content as a humectant Features of the RED Device Base Plates: RED Device Inserts are designed to be used with either the reusable PTFE or disposable high-density polypropylene base plates. Each RED Device Base Plate holds up to 48 RED Device Inserts and has a standard 96-well plate footprint with 9mm x 9mm well spacing to provide compatibility with automated liquid handling systems. In addition, the disposable RED Device Base Plates are available pre-loaded, providing operation convenience for scientists conducting protein-binding applications. No pre-conditioning of the membrane inserts is needed. When using radioactive materials, this single-use plate is easily disposed of to avoid contamination and cleaning. RED Device Inserts an |
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